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At present there are numbers of clinical studies regarding the L Lysine research that discovered the usefulness of lysine in preventing and sometimes shortening outbreaks of herpes simplex infections. Although, there were contrast results too that lysine cannot totally cure and has no effect on the patients. In vitro or outside the living body and in an artificial environment and animal studies have also found evidence of lysine's anti-herpetic effects.
The recently concluded l lysine research which was done in a double-blind, placebo-controlled operations in drug development for multicenter trial of oral lysine, the treatment group came across with 1000 mg of lysine three times daily (3000 mg daily) for six months. In that period, the treated subjects had an average of 2.4 fewer HSV infections, and their symptoms were drastically less severe and healing times evidently and significantly reduced.
In another randomized, l lysine research for a double blind, crossover study, a daily dose of 1248 mg (but not 624 mg) of lysine was found to reduce the recurrence rate of HSV in non-immunocompromised subjects too. But in this study, the 1248 mg dosage, which was in lesser dosage, did not shorten healing time.
There is another l lysine research that was done and has suggested that a supplemental lysine can both improve and augment intestinal absorption and improve renal conservation of absorbed calcium and that it might thus be helpful in osteoporosis. This l lysine research has to be pushed trough and accomplished because must of the women who are not herpes victims are suffering from osteoporosis which is alarming now a days.
This l lysine research has given away contraindication results too. It is that L-lysine supplementation is contraindicated in those with the rare genetic disorder hyperlysinemia/hyperlysinuria. For pregnant women and nursing mothers, a precaution for them is that they should only consider using supplemental L-lysine if their diets are low in this amino acid. They should avoid supplemental L-lysine for other reasons.
More so, in the l lysine research, it was found out that the proteins, which are high in L-lysine relative to L-arginine, are associated with elevated cholesterol levels. Those with hypercholesterolemia, which is known as a familial disorder that is characterized by an extremely high concentration of cholesterol in the blood and cells, should be warned of taking supplemental L-lysine too. Also for those who have hepatic or renal failure should exercise caution in the use of supplemental L-lysine.
The adverse reactions given in the l lysine research was a dose up to 3 grams daily are generally well tolerated. But a very high dose that could be greater than 10 to 15 grams daily may cause gastrointestinal symptoms, such as nausea, abdominal cramps and diarrhea.
It was in the early '70s that Dr. Richard Griffith and his colleagues at Indiana University showing the health benefits of taking supplements of the inexpensive and safe amino acid conducted one of the l lysine researches. The research recommended that cold-sore sufferers take 500 mg of lysine per 22 pounds of body weight daily. The news was published and sudenly one elderly cold-sore sufferer wrote, "Just to think, lysine was on the drugstore shelves all these years and I didn't know it." Dr. Richard Griffith said, “we are happy to keep spreading the word that boosting lysine intake and avoiding arginine-rich foods such as nuts and chocolates can help fight herpes simplex cold sores. “